氟西汀治疗心肌梗塞伴发抑郁

Efficacy of fluoxetine in treatment of depression in patients with acute myocardial infarction.

目的： 了解氟西汀治疗心肌梗塞伴发抑郁的疗效。 方法： 采用随机分组对照研究的方法， 将 ６８ 例心肌梗塞伴发抑郁症状病人分为两组， 治疗组用氟西汀， 对照组用安慰剂， 观察氟西汀疗效及对室性心律失常发生率的影响。采用 《汉密顿抑郁评定量表》评定疗效。 结果： 氟西汀对心梗伴发抑郁有显著缓解率 （９００％ ）， 明显高于对照组 （５２９％ ）， 并且其严重室性心律失常发生率 （３３％ ）明显低于对照组 （２６５％ ）。 结论： 氟西汀对心肌梗塞伴发的抑郁有良好疗效， 并能改善心梗病人的生活质量和预后。

Objective:To study the efficacy of fluoxetine in the treatment of depression in patients suffering from acute myocardial infarction . Method:68 patients with acute myocardial infarction suffering form depression were treated with either fluoxetine or placebo in a double-blind controlled trial for a period of four weeks.The subjects were monitored with HAMD for depressive symptoms and serial ECG for change of cardiac status. Results:Fluoxetine was effective in relieving depression in 90% of subjects,significantly better than the control group in which only 52.9% improved.Furthermore,there was significantly less ventricular arrhythmia in the fluoxetine group(3.3%) than control(26.5%). Conclusion:Fluoxetine is effective in the treatment of depression in patients suffering from acute myocardial infarction .