玻璃酸钠关节腔注射治疗膝关节骨性关节炎40例疗效观察

Articular Injection of Sodium Hyaluronate in Treatment 40 Cases of Knee Osteoarthritis

目的探讨玻璃酸钠关节腔注射治疗膝关节骨性关节炎的临床疗效。方法选择我院自2008年4月～2010年4月80例膝关节骨性关节炎患者作为研究对象,根据治疗方法的不同随机分为对照组和治疗组各40例,其中对照组采用曲安缩松关节腔注射,治疗组应用玻璃酸钠关节腔注射,连用5周,比较两组的疗效。治疗期间不用非甾体类抗炎药或其他免疫调节药物。结果随访2～8个月,治疗组总有效率87.50%,对照组70.00%,两组总有效率比较,差异有显著性(χ2=4.742,P<0.05)。且注射后1～2d内治疗组自诉患膝酸胀或疼痛不适者有2例,持续3d后自行消失。1例局部出现红、热、肿胀等现象,数小时自行消退。未见明显的全身不良反应,无一例发生感染。而对照组出现不适症状,如患膝酸胀或疼痛、红、热等不适人数达到13例。结论玻璃酸钠关节腔注射治疗膝关节骨性关节炎疗效确切,值得临床推广。

Objective To investigate the clinical efficacy intra-articular injection of sodium hyaluronate in treatment of knee osteoarthritis. Methods 80 cases of knee osteoarthritis patients as subjects cases were evaluated, according to the different treatments were randomLy divided into control group and treatment group 40 cases,including the control group song On shrinkage articular injection, the treatment group received sodium hyaluronate injection for 5 weeks. During treatment,not non-steroidal anti-inflammatory drugs or other immunomodulatory drugs. Results After 2- 8 months,the treatment group was 87.50% ,70.00% in control group effective rate,the difference was significant（ X 2=4.742,P〈0.05）. And 1- 2d after injection,the treatment group private prosecution knees soreness or discomfort in 2 cases,after continued 3d go away. 1 case local appears red,hot,swelling phenomenon,a few hours with spontaneous regression. No significant systemic adverse reactions,no one infected. The control group had symptoms,such as the risk of knee soreness or paln,red,hot number not reached total 13 cases. Conclusion The intra-articular injection of sodium hyaluronate in knee osteoarthritis treatment is effective, worthy of promotion.