休克兔间羟胺个体化给药和传统给药的疗效比较——电脑监测和自动给药系统(CAIMA)

A comparison on the curative of metaraminol in shock rabbits between individual and traditional administration——computer assisted instant monitoring and drug administration(CAIMA)

目的 :比较个体化给药和传统给药方式对升压药疗效的影响。方法 :实验性出血性休克家兔 ,一组 (CAIMA组 )用电脑实时监测血压 ,并由电脑自动控制间羟胺的给药速率 ,使血压维持在预置水平 ;另一组 (非CAIMA组 )用等量间羟胺匀速滴入 ;两组均联合应用山莨菪碱。结果 :CAIMA组血压稳定地维持在预置水平 ,血乳酸和肌酐值渐降 ;非CAIMA组血压有下降趋势 ,血乳酸和肌酐值有上升趋势。结论 :CAIMA组疗效优于非CAIMA组 ,因为CAIMA是按个体需求形成间歇性不规则给药方式 ,起到了智能泵的作用 ,真正体现了个体化给药的优点。

Aim: To compare the influence on the curative effects of metaraminol between individual and traditional administration.Methods:The blood pressure (BP) of experimental hemorrhagic shock rabbits was monitored continuomly.In group I ( CAIMA group),the rate of metaraminot(MET) administration was controlled by computor to keep BP at predetermined level.whereas in group Ⅱ,or non-CAIMA group,BP was kept at the same level by dripping the same amount of MET uniformly.Both groups was given anisodamine(654-2)simutaneously.Results:The BP of CAIMA group maintained at the same constant level as predetermined and blood concentrations of lactic acid and creatinine were all decreased;while in the non CAIMA group there was a decrease in BP but increase in blood concentrations of lactic acid and creatinine.Conclusion:Apparently the curative effects of CAIMA group is much better than that of non CAIMA group.CAIMA is a kind of intermittent irregular administration through a clever pump,which can fully reflect the advantages of traditional administration.