山莨菪碱与地塞米松联用增加MODS兔微循环灌注量的研究

The evaluation of the microcirculation in rabbit with multiple organ dysfunction syndrome after using alarge dose of anisodaminum and dexamathosonum

目的 :本研究旨在了解大剂量山莨菪碱及地塞米松对MODS兔的微循环变化。方法 :首先将日本大耳兔行盲肠结扎加穿孔 (CLP)造成腹腔感染致MODS的动物模型 ,其中实验组和对照组各 11只 ,应用瑞典PERIMED公司的新型 40 0 1双通道激光多普勒血流仪动态测定兔耳及大腿肌肉内在应用山莨菪碱及地塞米松时微循环的变化。结果 :对照组静注大剂量山莨菪碱及地塞米松后大腿肌肉内微循环的灌注量由 32 6 15± 87 32增加到 6 5 6 78± 10 2 5 0PU单位 ,兔耳微循环的灌注量由 8 5± 1 85增加到 11 49± 3 42PU单位。实验组静注大剂量山莨菪碱及地塞米松后大腿肌肉内微循环的灌注量由 2 90 5 0± 2 0 18增加到 6 91 39± 10 2 0 7PU单位。兔耳微循环的灌注量由 5 36± 3 2 6增加到 19 78± 10 10PU单位。结论 :山莨菪碱与地塞米松联用增加MODS兔微循环的灌注量 ,这对保护和维持重要脏器的功能十分有利。

Aim:The microcirculation of rabbits with multiple organ dysfunction syndrome(MODS)after using large dose of anisodaminum and dexamathosonum has been observed.Methods:First we used the methods of cecum ligation and perfusion to create the model of MODS,then used Perifix 4001 Master laser doppler to evaluate the real time microvascular perfusion after using alarge dose of anisodaminum and dexamathosonum.Results:In health group,the microvascular perfusion in leg muscules was from 326 15±87 32 increasing to 656 78±102 5 PU and in ear from 8 5±1 85 to 11 49±3 42 PU after using the drugs;in MODS group,the microvascular perfusion in leg musculse was from 290 5±20 18 increasing to 691 39±102 07 PU and in the ear from 5 36±3 26 to 19 78±10 1 PU after using the drug.Conclusion:It is suggested that a large dose of anisodaminum and dexamathosonum can improve the microcirculation in MODS.