静注大剂量丙种球蛋白治疗小儿耐药菌感染

Clinical effects of intravenous use of high dose immunoglobulin in children with antibiotic resistant bacterial infection

目的 探讨静注大剂量丙种球蛋白（ Ｉ Ｖ Ｉ Ｇ） 对小儿耐药菌感染性疾病的疗效。方法 将１９ 例耐药菌感染随机分组治疗，观察组采用 Ｉ Ｖ Ｉ Ｇ（２００ ～３００ ｍｇ／ｄ ，用２ ～３ 天） 治疗小儿耐药菌感染９例。结果 有效率１００ ％ ，与对照组相比，１２ ～２４ ｈ 后发热、咳喘憋渐缓解，病程缩短３ ～７ 天。结论 Ｉ Ｖ Ｉ Ｇ 能迅速改善小儿耐药菌感染的症状，明显缩短病程和提高治愈率。

Objective To observe the clinical effects of intravenous high dose immunoglobulin (IVIG) in children with antibiotic resistant bacterial infection.Methods 19 children with antibiotic resistant bacterial infection were randomly divided into IVIG group 9 cases and control group(10 cases)respectively. Immunoglobulin was intravenously injected together with conventional treatment for IVIG group 200～300 mg/(kg·d) for 3 days.Results The clinical efficiency rate was 100% in IVIG group.The fever,cough and gasp were gradually alleviated after 12～24 hours IVIG treatment.The course of diseases was shortened 3～7 days.Conclusion IVIG therapy could rapidly improve the symptoms of the children with antibiotic resistant bacterial infections.The course of diseases could be shortened and its cure rate was inceased significantly.