摘要
目的：探索促甲状腺素释放激素（TRH）对烧伤休克的作用。方法：采用大鼠40％TBSAⅡ度烧伤休克的动物模型，观察TRH对烧伤前后平均动脉压的动态变化，生存时间，血浆SOD活力和MDA含量，心、肝肺、肾和创面含水量以及肾病理形态学和心肌细胞超微结构的影响。结果：TRH能显著提高休克动物的血压，延长生存时间，能防止血浆SOD活力的下降，抑制MDA的升高，减轻器官组织水肿和缺血缺氧性损害。结论：TRH具有良好的抗烧伤休克作用。
This study is to invest igate t he effects of thyrotropin releasing hormone (TRH ) un burn shock. Methods: A rat shock model with 40% TBSA 2nd degree burn wasused. The influence of TRH on the changes of the mean arterial pressure (MAP), the survival time,Superoxide dismutase (SOD) activities and malondialdehyde (MDA) content of the plasma, watercontent of the heart, liver, lungs, kidney and burnt skin, the light micrograph of the kidney and theelectron micrograph of cardiomyocyte ultrastructure were investigated. Results: TRH could raise theMAP, prolong the survival time, prevent the decline of SOD activities, depress the elevation of MDAcontent and alleviate edema and damage of the organs. Conclusion: TRH exerts therapeutic effects onrat burn shock.
出处
《中国烧伤创疡杂志》
1999年第3期4-7,共4页
The Chinese Journal of Burns Wounds & Surface Ulcers
关键词
烧伤
休克
TRH
Thyrotropin-releasing hormone Burn shock
