大肠腺癌EGFR和ras p21表达与淋巴结转移的关系

CORRELATION BETWEEN EXPRESSIONS OF EGFR AND ras p21 IN COLORECTAL ADENOCARCINOMAS AND LYMPH NODE METASTASIS

目的探索大肠腺癌ＥＧＦＲ和ｒａｓｐ２１表达与淋巴结转移的关系。方法采用免疫组织化学ＬＳＡＢ法，对７０例大肠腺癌连续切片组织同步进行ＥＧＦＲ和ｒａｓｐ２１检测。结果在有淋巴结转移的３５例大肠腺癌中，ＥＧＦＲ、ｒａｓｐ２１及ＥＧＦＲ和ｒａｓｐ２１共同呈阳性表达者分别是２４例（６８．６％）、２８例（８０．０％）和２２例（６２．９％），在无淋巴结转移的３５例大肠腺癌中，ＥＧＦＲ、ｒａｓｐ２１及ＥＧＦＲ和ｒａｓｐ２１共同呈阳性表达者分别是９例（２５．７％）、１２例（３４．３％）和３例（８．６％），前者的阳性表达率均非常显著地高于后者（Ｐ＜０．０１）。结论大肠腺癌ＥＧＦＲ或／和ｒａｓｐ２１阳性表达与淋巴结转移密切相关。对术前判断淋巴结转移和拟定手术方式等方面起指导作用。

Objective To investigate the correlation between expressions of EGFR and ras p21 in colorectal adenocarcinomas and lymph node metastasis.Methods The expressions of EGFR and ras p21 in serial tissue sections in large intestine adenocarcinomas were studied in 70 cases by LSAB immunohistochemical technique. Results The positive expressions of EGFR, ras p21 and EGFR with ras p21 were respectively revealed in 24 cases(68.6%),28 cases(80.0%) and 22 cases (62.9%) among 35 cases of colorectal adenocarcimomas with lymph node metastasis. However,the results of the above three items were differently revealed in 9 cases(25.7%),12 cases (34.3%) and 3 cases (8.6%) among 35 cases of colorectal adenocarcinomas without lymph node metastasis.The former was significantly higher than the latter in the rates of positive expressions(P<0.01).Conclusion The positive expression of EGFR or ras p21 or EGFR with ras p21 in colorectal adenocarcinomas is closely correlated with lymphatic metastasis. lt plays an instructive part in adjudging preoperatively whether there is lymphatic metastasis or not,and in designing operation.