直肠癌旁粘膜中细胞动力学的研究

A STUDY OF THE CELLULAR KINETICS IN THE MUCOSA ADJACENT TO RECTAL CANCER

目的探讨直肠癌旁粘膜的细胞生物学特性和范围大小。方法应用放射自显影双标记法检测１０例直肠癌旁粘膜的细胞动力学参数。结果距腺癌８ｃｍ范围内的肠粘膜，与正常粘膜相比，均有明显的腺体标记细胞上移、标记指数（ＬＩ）升高、细胞ＤＮＡ合成时长（Ｔｓ）延长、细胞周期时长（Ｔｃ）缩短。且上述变化呈现移行趋势，即距离腺癌越近，其异常变化的程度亦相对越重。结论直肠癌旁粘膜很可能属于癌前病变，其范围应不小于８ｃｍ。

Objective To investigate the cell biological nature and extent of mucosa adjacent to rectal adenocarcinoma.Methods The cytokinetic changes of mucosa adjacent to 10 rectal adenocarcinomas were determined by autoradiography.Results Compared with normal mucosa,the mucosa adjacent (within 8 cm) to tumor had following abnormal alterations:1) moved up labelled cells in crypts,2) increased labelling index,3)prolonged DNA synthesis time,and 4)shortened cell cycle.Moreover,the above abnormal changes of mucosa had a transitional trend:the closer to the cancer, the more evident alterations were showed.Conclusion The peritumorous mucosa might be precancerous, and the range would be no less than 8 cm beside the tumor mass.