粘附分子CD_(44)的蛋白表达及其与胃癌淋巴结转移的关系

EXPRESSION OF CD 44 IN GASTRIC CARCINOMA AND ITS CLINICAL SIGNIFICANCE

目的研究粘附分子ＣＤ４４与胃癌淋巴结转移的关系。方法应用ＬＳＡＮ免疫组化方法检测４５例原发性胃癌标本中ＣＤ４４的表达。结果ＣＤ４４的阳性表达率为６０％。染色特征为细胞膜着色。ＣＤ４４的表达强度与胃癌的分化程度、浸润深度无相关性（Ｐ＞０．０５），与胃癌的淋巴结转移呈正相关（Ｐｅａｒｓｏｎ列联系数Ｐ＝０．７９，Ｐ＜０．０５）。结论粘附分子ＣＤ４４在胃癌的淋巴结转移中起了一定的促进作用，对ＣＤ４４的检测可以成为预测肿瘤转移的指标。

Objective To research the relation of CD 44 and gastric carcinoma. Methods The expression of CD 44 were examined on 45 cases of gastric carcinomas by LSAB means.Results The positive rate of CD 44 was 60%. The expression of CD 44 wasn′t correlated with the grade of tumor differentiation and the depth of invasion of gastric carcinoma(P<0.05).Its expression was positively correlated with the lymphnode metastasis (P<0.05). Conclusion CD 44 plays an important role in gastric carcinoma metastasis and lymphnode metastasis. Determination of CD 44 might be useful in the prediction of tumor metastasis.