孕母血清抗风疹病毒IgM抗体测定对胎儿先天性心脏病诊断意义的探讨

Rubella virus antibody IgM and fetal congenital heart disease

目的:了解抗风疹病毒IgM测定在诊断胎儿先天性心脏病(简称先心病)中的价值。方法:对102例孕母(其中50例孕母妊娠早期患上呼吸道感染,另52例孕期无上呼吸道感染)抽血检测血清抗风疹病毒IgM抗体(抗RV-IgM),同时进行胎儿超声心动图检查,生后复查超声心动图。结果:孕母抗RV-IgM抗体阳性11例(10.8%),其中8例胎儿有先心病(72.7%),其灵敏度38.1%,特异度95.1%;精确比(诊断符合率)84.4%;阳性预测值(阳性确诊率)72.7%。阴性预测值(阴性确诊率)85.7%,误诊率27.3%,漏诊率14.3%。

Objective:To understand the value of the mother serum rubella virus antibody IgM determination in diagnosis of fetal congenital heart disease (FCHD). Methods:Serum rubella virus antibody IgM and fetal echocardiography were examined in 102 pregnancies and repeated in suspicious FCHD cases after birth. Results:11 pregnancies were RV IgM positive (10.8%), in which 8 cases with FCHD (72.7%). After statistical calculation, the diagnostic sensitivity was 38.1%, specificity 95%; accuracy 84.4%, positive predictive value 72.7%, negative predictive value 85.7%, error diagnostic rate 27.3% and the misdiagnostic rate 14.3%. Conclusion:Serum rubella virus antibody IgM determination in pregnancy is very valuable method used as screening for FCHD.