T大颗粒淋巴细胞白血病

T large granular lymphocytic leukemia

目的:为了进一步认识T大颗粒淋巴细胞白血病(T-LGLL)的临床及生物学特性,提高诊断水平。方法:利用细胞形态学,细胞化学及免疫分型检查分析3例T-LGLL。结果:3例均有大颗粒淋巴细胞(LGL)明显升高。细胞化学染色:POX(-),PAS阳性率100%,ANAE:T样酶型(+),ACP(+),TRAP(-)。免疫表型CD2(+),CD3(+),CD4(-),CD8(+),CD57(+),TCRαβ(+)。结论:T-LGLL是白血病中一种少见的独特类型,必须认真检查细胞形态,才能避免漏误诊断;

Objective:To further define the clinical and biologic feature of T large granular lymphocytic leukemia (T LGLL), and elevate the level of diagnosis. Methods:3 cases T LGLL were analysed by cell/tissue morphology and cytochemistry and immunophenotyping. Results:The characteristic finding is the presence of increased numbers of LGL in 3 cases. Cytochemistry: POX(-), PAS(+), ANAE: T like(+), ACP(+), TRAP(-). Immunophenotyping: CD2(+),CD3(+),CD4(-),CD8(+),CD57(+),TCR αβ (+).Conclusion:T LGLL is a special type of leukemia. Careful examination of the peripheral blood smear is mandatory for avoiding misdiagnosis and missing diagnosis. Immunophenotype showed important value.