九组十种药物对HBV血清标志物转阴疗效观察

OBSERVATION ON ELIMINATING EFFECTS OF SERUM HBV MARKERS WITH 9 GROUPS (TOTAL 10 TYPES)OF DRUGS

应用干扰素等九组十种药物分别治疗慢性乙型肝炎309例,旨在促使血清标志物阴转。结果表明,九组十种药物对复制指标转阴均有不同程度的作用,而以干扰素组效果最好。对HBsAg转阴除去自然转阴率基本无效。作者认为,在目前没有特效抗病毒药物的情况下,如仅HBsAg(+)、抗HBe(+)、抗HBc(+)或HBsAg(+)、抗HBc(+)而其它复制指标阴性者,不需转阴治疗。

309 cases of chronic hepatitis B were treated with 9 groups (total 10 types) of drugs including interferon, thymosin, transfer factor etc, respectively to eliminate the scrum markers.The results showed that the drugs were effective to transfer the positive replicating markers to negtive and had. no effect on HBsAg elimtna- tion. Interferon ranked the first on the replicating markers.So the authors suggest that since there are no effective antiviral agents, such carriers who have positive HBsAg, anti-HBc and anti-HBc or positive HBsAg and anti-HBc, should not he treated, So the drugs can be saved and the expense lowered.