不同剂量麻黄碱对顺式阿曲库铵肌松效应的影响

The effect of different dosage of ephedrine on reduce the onset time of cisatracurium

目的观察不同剂量麻黄碱对顺式阿曲库铵(Cis)肌松效应的影响。方法患者75例,ASAⅠ或Ⅱ级,随机均分为三组:P1、P2和C组。P1组:1%丙泊酚+0.5mg/ml麻黄碱,P2组:1%丙泊酚+0.75mg/ml麻黄碱,C组:1%丙泊酚+相同容量的生理盐水。记录肌松起效时间、肌松恢复时间、气管插管条件和插管期间的血流动力学变化。结果 P2组起效时间、95%恢复时间、肌松完全恢复时间、5%～95%恢复指数明显快于C组(P<0.05或P<0.01)。P2组在插管1min时MAP明显上升,HR明显增快(P<0.05);C组在插管即刻和插管1min时MAP明显下降,HR明显减慢(P<0.01)。插管条件P2组明显好于C组(P<0.05)。结论 1%丙泊酚+0.75mg/ml小剂量麻黄碱联合麻醉诱导后≤4min时,再给予Cis0.15mg/kg可有效缩短起效时间和95%恢复时间,同时能够改善气管插管条件。

Objective To evaluate the effect of different dosage of ephedrine on reduce the onset time of eisatracuriurn. Methods Seventy-five ASA Ⅰ or Ⅱ patients were randomly divided into three groups （n= 25, each group） ： group P1（ 1% propofol＋ 0. 5 mg/ml ephedrine）, group P2 （ 1% propofol＋0. 75 mg/ml ephedrine）, and control group C （1% propofol＋ saline）. Cisatraeurium was administered at ≤4 min afterl% propofol 1.5 mg/kg was given. Onset time, recovery time of muscle relax and the situation of intubation were recorded. The hemodynamie parameters were measured at the time of the intubation. Results The onset time, recovery time of eisatraeurium in the group P2 were significantly shorter than group C（P（0.05）. MAP and HR 1 rain after tracheal intubation in group P2 was increased. The clinical intubating condition in group P2 was better than group C （P〈0.05）. Conclusion Combination 1% propofol and 0.75 mg/ml ephedrine, given at ≤4 min before administering 0.15 mg/kg eisatraeurium, could significantly shorter the onset time and 95% of recovery time of cisatracurium and improve clinical intubating conditions.