氯苯丁酯对大鼠口服呋喃氟脲嘧啶药代动力学的影响

THE INFLUENCE OF CLOFIBRATE ON THE PHARMACOKINETICS OF FTORAFUR IN RATS

用交叉实验设计法研究了氯苯丁酯对10只大鼠口服呋喃氟脲嘧啶(FT-207)药代动力学的影响。反相高效液相色谱法测定血清FT-207浓度,其药时曲线符合一室开放模型。大鼠连续口服氯苯丁酯180mg/kg/d×5d,可促进FT-207吸收,使Ka增加90.9％,Ta1/2缩短48.6％,Tmax缩短38.2％,Cmax增加12.4％。文中简要讨论了二药相互作用的临床意义。

The influence of clofibrate on the pharmacokinetics in ten rats given ftorafur orally were investigated with cross-over design. The concentration of ftorafur in serum was determined by reversed phase high performance liquid chromatography and its curve of con- centration vs time was fit to one-compartment opened model. Absorp- tion of ftorafur may be increased when clofibrate given 180 mg/kg daily for five days. The ka and peak serum level of ftorafur increased by 90.9% and 12.4%,respectively. Its Tmax and Ta1/2 decreased by 38.2% and 48.6%,respectively. Clinical significance of interaction between clofi- brate and ftorafur were discussed in the paper.