水林佳(水飞蓟宾-磷脂复合物)治疗非酒精性脂肪性肝病60例临床疗效观察

Observation of therapeutic effects of Silibinin Capsules to treat sixty cases of nonalcoholic fatty liver disease

目的:观察水林佳(水飞蓟宾-磷脂复合物)治疗非酒精性脂肪性肝病的临床疗效。方法:将60例患者随机分为两组,治疗组给予水林佳口服,对照组予以护肝片口服,3个月为1个疗程,疗程结束后,观察临床症状、体征、肝功能及TC、TG和超声影像的变化,同时对两组患者用药期间不良反应进行观测。结果:治疗组和对照组总有效率分别为93.3%及73.3%,两组比较差异有统计学意义(P<0.05)。治疗组在改善患者临床症状、肝功能、血脂及超声影像方面疗效显著,无明显不良反应。结论:水林佳治疗非酒精性脂肪性肝病临床疗效确切。

Objective： To observe the clinical effects of Silibinin Capsules to treat nonalcoholic iatty liver disease. Methods： The sixty cases were randomly divided into two groups. The treatment group received Silibinin Capsules for oral administration and the control group took orally liver-protecting tablet, three months for a course of treatment. Clinical symptoms and physical signs and liver function and TC, TG and the changes of ultrasonographie image after treatment were observed. At the same time, the adverse reactions were observed in the two groups during the treatment. Results： The total effective rate of treatment group and control group were 93.3% and 73.3% respectively, there was notable difference between two groups （P〈0.05）. Patients of the treatment group in improving clinical symptoms, liver function, blood lipids and ultrasonographic image sides had significant curative effect, without significant adverse reactions. Conclusion： Silibinin Capsules in treatment of nonalcoholic fatty liver disease is effective.