卡亚叶总黄酮提取物对四氧嘧啶诱导的糖尿病大鼠降血糖作用

Hypoglycemic Effect of Total Flavonoids Extract from Chaya Leaves in Alloxan-induced Diabetic Rats

目的:研究卡亚叶总黄酮提取物降血糖作用。方法:将44只大鼠随机分成正常对照组(普通饲料)、模型组(ALX)、高、低剂量组(ALX+卡亚叶总黄酮提取物剂量分别为0.21、0.14g/kg)和药物治疗对照组(ALX+盐酸二甲双胍),分笼喂养28d,测定实验中大鼠血清的空腹血糖(FPG)、耐糖量(OGTT)、糖化血清蛋白(GSP)、谷丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、尿素氮(BUN)、总胆固醇(TC)、血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)的水平。结果:卡亚叶总黄酮提取物可明显降低ALX大鼠血清FPG、OGTT、GSP、ALT、AST、BUN、TG和LDL-C(P<0.05),升高HDL-C含量(P<0.05),可明显增加ALX大鼠体质量(P<0.05)。结论:卡亚叶总黄酮提取物可有效改善糖尿病大鼠体质量减轻状况,对ALX大鼠有辅助降血糖作用。

Purpose： To investigate the hypoglycemic effect of Chaya leaf total flavonoids extract（CLTFE） on alloxan（ALX）-induced diabetic rats.Methods： A total of 44 rats were randomly divided into normal control group（normal feed）,model control group（ALX）,drug treatment control group（ALX ＋ Metformin hydrochloride） and CLTFE treatment groups（ALX ＋ CLTFE at the high and low dosages of 0.21 g/kg and 0.14 g/kg,respectively）.The serum levels of fasting blood glucose（FPG）,oral glucose tolerance test（OGTT）,glycosylated serum protein（GSP）,alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,blood urea nitrogen（BUN）,total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein cholesterol（LDL-C） and high-density lipoprotein cholesterol（HDL-C） of rats in each group were determined after consecutive feeding for 28 days.Results： CLTFE significantly reduced the serum levels of FPG,OGTT,GSP,ALT,AST,BUN,TG and LDL-C（P〈0.05） in ALX-induced rats,and significantly increased the serum level of HDL-C and body weight of ALX-induced rats（P〈0.05）.Conclusion： CLTFE can improve the situation of weight loss in diabetic rats,and have auxiliary hypoglycemic effect in alloxan-induced diabetic rats.