COX-2和Ki-67在膀胱移行细胞癌中的表达及其意义

Expression of COX-2 and Ki-67 in the Bladder Transitional Cell Carcinoma and the Significance

目的:探讨环氧化酶-2(COX-2)和Ki-67在膀胱癌中的表达及其意义。方法:应用免疫组化S-P法检测52例膀胱移行细胞癌和12例正常膀胱组织中COX-2和Ki-67的表达。结果:COX-2和Ki-67在癌旁组织中均不表达,而在各级别的膀胱移行细胞癌中均有表达,二者差异有统计学意义(P<0.05)。结论:COX-2可以作为评估膀胱移行细胞癌细胞增殖的良好指标,COX-2和Ki-67的表达可以判断膀胱移行细胞癌的恶性程度。

Objective： To investigate the expression of COX-2 and Ki-67 in he bladder transitional cell carcinoma and the significance.Methods： The expression of COX-2 and Ki-67 was detected by S-P immunohistochemical technique in the bladder transitional cell carcinoma（n=52） and normal tissues（n=12）.Results： The COX-2 and Ki-67 were not expressed in the all normal tissue,but the expression of COX-2 and Ki-67 could be detected in different grades of he bladder transitional cell carcinoma.The positive rate of COX-2 and Ki-67 expression in high grade group was significant higher than that in low grade group（P0.05）.Conclusion： The expression level of COX-2 correlate significantly with proliferating activity ofhe bladder transitional cell carcinoma cell.The expression of COX-2 and Ki-67 Evaluate the malignancy degree of the bladder transitional cell carcinoma.