首发精神分裂症患者的未治疗期与社会功能缺陷的关系

Relation of the social function defect with the untreated phase in patients with first-episode schizophrenia

目的探讨首发精神分裂症患者的未治疗期与社会功能缺陷的关系。方法对200例首发精神分裂症患者进行有关未治疗期及社会功能缺陷的调查,于治疗前和出院半年后采用社会功能缺陷评定量表(SDSS)进行评定,以未治疗期<1年122例为研究组,≥1年78例为对照组,比较两组社会功能缺陷的差异及半年后社会功能恢复情况。结果研究组的平均未治疗期为(0.33±0.26)年,显著短于对照组的(1.97±0.89)年(P<0.01);经过住院治疗和出院维持治疗半年后,两组的SDSS总分和各因子分均有显著改善,但SDSS总分和职业功能、社会活动、家庭活动和生活能力等方面以研究组显著优于对照组(P<0.05或P<0.01)。研究组出院半年后社会功能有显著改善,从业比例极显著高于对照组(P<0.01),半年内复发的比例研究组显著低于对照组(P<0.05)。结论精神分裂症患者的未治疗期与其社会功能缺陷密切相关,因此,应重视早期干预治疗。

Objective To explore the relation of the social function defect with the untreated phase in patients with first-episods,schizophrenia.Methods Totally 200 patients with first-episode schizophrenia were tested social function with social disability screening schedule（SDSS）before treatment and were divided into two groups according to untreated phase.The study group（n=122）had shorter untreated phase within one year and the control group（n=78）had longer untreated phase reach or over one year.The general data and SDSS results of before treatment and after six months of discharge from hospital were compared to show the relation of the social function defect with the untreated phase.Results The mean untreated phase in the study group was（0.33±0.26）year which showed shorter than that in the control（1.97±0.89）years（P0.01）.After six months＇ treatment of discharge from hospital,SDSS total scores and factors scores showed significantly improved in both groups,But,after intervention,in the study group,the functions of occupation,social activity,family duty and life ability improved more obviously than in the control（P0.05 or 0.01）.The proportion of getting a job showed higher（P0.01）and the proportion of ill re-onset showed lower（P0.05）in the study group than in the control.Conclusion There has close relation of the social function defect with the untreated phase in patients with first-episode schizophrenia.Early intervention or treatment must be done to improve social function.