舍曲林合并理性情绪疗法治疗强迫症对照研究

Control Study on Sertraline Conbined with Rational-emotive Therapy in Treatment of Obsessive-compulsive Disorder

目的探讨舍曲林合并理性情绪疗法对强迫症的治疗效果。方法将56例在门诊治疗的强迫症患者分成两组,分别用理性情绪疗法合并舍曲林(28例为观察组)和单用舍曲林(28例为对照组)治疗;于入组时、治疗6周、6个月及1年后分别用Y-BOCS量表、HAMA量表评定病人,并于治疗1年后用SDSS量表评定病人。结果 1治疗6周后两组临床疗效差异有统计学意义(χ2=5.536,P<0.05);2治疗6周后两组Y-BOCS减分值差异有统计学意义(t=5.45,P=0.02);3治疗半年后两组HAMA减分值差异有统计学意义(t=9.68,P=0.006);4治疗1年后两组SDSS减分值差异有统计学意义(P<0.05)。结论舍曲林合并理性情绪疗法联合治疗强迫症效果优于单用舍曲林治疗,病人容易接受。

Objective To explore the effect of Sertraline conbined with rational-emotive therapy on obsessive-compulsive disorder.Methods A total of 56 patients with obsessive-compulsive disorders in outpatient were divided into two groups,and treated by Sertraline combined with rational-emotive therapy（28 cases for the observation group）,and only by Sertraline（28 cases in the control group） respectively.The results were assessed by Y-BOCS and HAMA when grouping,after 6 weeks,6 months and 1 year of treatment respectively,and assessed by SDSS after 1 year of treatment.Results ①After 6 weeks of treatment,the efficacies of the two groups showed statistical significance（χ2=5.536,P0.05）;②after 6 weeks of treatment,the deduction values of Y-BOCS scores of the two groups showed significant differences（t=5.45,P0.02）;③after 6 months of treatment,the deduction values of HAMA scores of the two groups showed significant differences（t=0.968,P=0.006）;④after 1 year of treatment,the deduction values of SDSS scores of the two groups showed significant differences（P0.05）.Conclusion The effect of Sertraline conbined with rational emotive therapy on obsessive-compulsive disorder is better than that only by Sertraline,the patients were acceptable.