年龄、职业和免疫因素与系统性红斑狼疮及狼疮性肾炎的关系

The correlation between factors of Age, Occupation, Immnuity, Systemic Lupus Eythematosus and Lupus Nephritis

目的评价年龄、职业和免疫冈素与系统性红斑狼疮及狼疮性。肾炎的关系。方法收集2009年本院风湿免疫科住院的172例系统性红斑狼疮患者，将病人分为狼疮性肾炎和非狼疮性肾炎组，分析两组病人的年龄分布情况，并对这两组病人的抗核抗体（ANA）、抗ENA抗体和补体C3、C4进行检测。结果本研究的系统性红斑狼疮病人中，农民患者人数最多，占38．3％；狼疮性肾炎和非狼疮性肾炎组患者的年龄分布一致，均主要集中存15～44年龄段；两组患者的核型和15种抗体的阳性率没有统计学差异；狼疮性肾炎和非狼疮性肾炎组的C3与C4值均具有正相关的趋势（相关系数为0．85），并且狼疮性肾炎组病人的C3值明显低于非狼疮性肾炎组（P=0．03）。结论性别、年龄、工作生活环境及ANA、C3、C4对系统性红斑狼疮的诊断具有很大的价值，其中补体c3对评价系统性红斑狼疮和狼疮性肾炎有较大的意义。

Objective To explore the correlation between factors of age,occupation,immunity, systemic lupus eythematosus （SLE） and lupus nephritis （LN）. Methods One hundred and seventy-two SLE patients were collected from inpatients of Department of Rheumatism, The First Affiliated Hospital, Harbin Medical University in 2009. Patients were divided into lupus nephritis and non-lupus nephritis group. Age distributions of these two groups of patients were analyzed. ANA, anti-ENA antibodies, and complements （C3, C4） were examined. Results Most patients with SLE in this study were farmers; Lupus nephritis and non-lupus nephritis patients had the same age distribution, and mainly concentrated in the 15-44 age group; Differences of the nuclear-type and the positive rates of 15 kinds of antibody in the two groups were not statistically significant; The C3 counts of patients with lupus nephritis was significantly lower than patients without lupus nephritis （ P = 0. 03 ）, and there was positively correlation between the levels of C3 and C4 in all patients （ r = 0. 85 ）. Conclusions Gender, age, working and living environment, ANA, C3, C4 had great value to the diagnosis of systemic lupus erythematosus, especially, complement C3 had a greater significancon for diagnosis of systemic lupus erythematosus and lupus nephritis.