参芪地黄汤联合二甲双胍治疗糖尿病肾病27例的疗效观察

Efficacy analysis on the treatment of diabetic nephropathy with Shengqidihuang decoction combined with metformin

目的 观察参芪地黄汤联合二甲双胍治疗糖尿病肾病的临床疗效。方法54例糖尿病肾病患者按照随机数字表法分为两组各27例，两组患者均进行糖尿病常规治疗。对照组在糖尿病常规治疗的基础上口服二甲双胍0．25mg／次，3次／d，连服8周；治疗组在对照组的基础上加服参芪地黄汤加减治疗，1剂／d，4周为1个疗程，治疗2个疗程，两组患者均于治疗前后分别检测24小时尿蛋白定量（24hUAE）、血清肌酐（SCr）、血尿素氮（BuN）、空腹血糖（FBG），并行疗效评定。结果治疗组总有效率为85．2％，对照组为66．7％，两组总有效率比较，差异有统计学意义（X^2=3．376，P〈0．05）；治疗组24hUAE、SCr、BUN、FBG与对照组治疗后以及与同组治疗前组比较，差异均有统计学意义（X^2分别为4．231、3．754，P均〈0．05）。结论采用参芪地黄汤联合二甲双胍治疗糖尿病肾病，疗效优于单纯用二甲双胍治疗。

Objective To observe the clinical effect of treating diabetic nephropathy with Shengqidihuang decoction combined with metformin. Methods 54 cases with diabetic nephropathy were randomly divided into two groups by means of random number table. Both groups were given diabetic routine treatment. The control group was treated with metformin, 0.25 mg each time, three times a day, based on the diabetic routine treatment for 8 weeks, and the treatment group was treated with Shengqidihuang decoction, once a day, 4 weeks as a course, continuously treated for 2 courses based on the control group. 24 h urinary protein （24hUAE） , serum creatinine （SCr） , blood urea nitrogen （BUN） and fasting blood glucose （FBG） were detected before and after the treatment. The clinical effect was observed between the two groups after the treatment. Results The total effective rate of the treatment group and the control group was 85.2% and 66.7% respectively, showing a significant difference （X^2=3.376, P〈0.05）. Compared with the control group, 24hUAE, SCr, BUN and FBG in the treatment group decreased significantly （X^2=4.231, P〈0.05） after the treatment. 24hUAE, SCr, BUN and FBG decreased significantly after the treatment, especially in the treatment group, also showing a significant difference （X^2=3.754, P〈0.05）. Conclusion The therapy ofmetformin combined with Shengqidihuang decoction on diabetic nephropathy was better than metformin only.