血清胱抑素C在2型糖尿病肾病早期诊断中的临床应用评价

目的评价血清胱抑素C在2型糖尿病肾病早期诊断中的临床诊断价值。方法选择2型糖尿病患者126例,根据尿白蛋白排泄率(UAER)的不同分为A组、B组和C组,并选择同期健康体检者40例作为正常组,分别检测血清胱抑素C(CysC)、血肌酐(Scr)、尿素氮(BUN),并对检测结果进行统计分析。结果糖尿病肾病早期阶段,Scr、BUN水平改变不明显,在糖尿病肾病发展的各阶段CysC水平改变具有差异性;早期糖尿病肾病CysC的敏感性明显高于其他两项指标,比较具有(高度)统计学意义(P<0.01,P<0.05)。结论 CysC可作为临床早期糖尿病肾病诊断的可靠指标。

Objective To evaluate clinical diagnosis value of serum cystatin C in early type 2 diabetic nephropathy.Methods Collect 126 patients with type 2 diabetic nephropathy,they were divided into A group,B group and C group by the difference of urinary albumin excretion rate（UAER）,40 healthy people were divided into normal group,then detect serum cystatin C（Cys C）,serum creatinine（Scr）,blood urea nitrogen（BUN） and analyse the test results.Results The change of Scr,BUN level were not obvious in the early stages of diabetic nephropathy;the change of Cys C level was obvious in each stage of diabetic nephropathy development;the sensitivity of Cys C was significantly higher than the other two indicators（P0.01,P0.05）.Conclusion Cys C could be used as a reliable indicator in early diagnosis of type 2 diabetic nephropathy.