微RNA-106b～25基因簇在肿瘤中的研究进展

Advances in study of miR-106b-25 duster in cancer

微RNA（miRNA）-106b-25基因簇由miR-106b、miR-93及miR-25组成，与miR-17～92原癌基因簇有着极高的同源性。已有的研究表明，该簇miRNA成员在多种肿瘤中高表达。这些miR通过抑制细胞周期抑制因子p21、p57及凋亡抑制因子Bim来促进肿瘤细胞增殖，抑制细胞凋亡。在转化生长因子β（TGF—β）信号通路中，miR-106b25的高表达可使肿瘤细胞逃避TGF—β诱导的生长抑制作用。

miR-106b-25 cluster is composed of miR-106b, miR-93 and miR-25 ,and is a paralogue of miR-17-92 cluster. Some studies have shown that the members in miR-106b-25 cluster abundantly expressed in many cancers. Over-expressions of these miRNAs promote the growth of tumor cells by negatively regulating p21 and p57, and suppress the apoptosis of tumor cells through inhibition of Bim. Moreover, high expression of miR-106b-25 cluster might endue tumor cells with resistance to inhibitory effect of cell growth induced by TGF-β signaling.