真核延伸因子1A2与肿瘤

Recent advances in eukaryotic elongation factor 1 alpha 2 and tumor

正常情况下在翻译延伸阶段发挥作用的真核延伸因子1A2（eEF1A2）仅在脑、心脏以及骨骼肌中表达，但最近的研究却发现eEF1A2在许多肿瘤中呈高表达状态且与肿瘤的发生发展密切相关。随着对其在肿瘤发生发展过程中信号传导机制研究的深入，eEF1A2可能成为肿瘤治疗的一个新靶点。

Eukaryotic elongation factor 1 alpha 2（eEF1A2）, which plays a role in the translational elongation process, is normally expressed only in the heart, brain and skeletal musle, but recent studies found it is highly expressed in a variety of tumors and closely related to the oncogenesis and development of tumor. As the signal transduction mechanism is clarified, eEF1A2 is likely to become a novel target for tumor therapy.