胃泌素高表达型大肠癌差异蛋白质组学的研究进展

Advance in differential proteomics of high expression of gastrin-based eolorectal neoplasms research

部分大肠癌的发生发展与胃泌素及其受体的异常表达密切相关，胃泌素及其受体的高表达促进大肠癌细胞增殖并抑制凋亡，其生物学行为主要通过蛋白质的异常表达实现。运用差异蛋白质组学研究方法能够找出胃泌素高表达型大肠癌在发生发展过程中的差异蛋白，进而通过对特定蛋白质的调节实现预防及治疗大肠癌的目的。

The abnormal expression of gastrins and their receptors have close relationship with the occurrenceand the development of some colorectal neoplasms. The high expression of gastrins and their receptors promote colorectal neoplasms cell proliferation and inhibit apoptosis. The biological behavior is mainly rely on the abnormal expression of protein. Using differential proteomics can screen differential expression protein of high expression of gastrin-based colorectal neoplasms in the occurrence and development process, and then with the regulation of specific proteins to achieve the prevention and treatment of colorectal neoplasms purposes.