新疆维吾尔族妇女宫颈癌HPV感染型别分布研究

Distribution of human papillomavirus types in cervical cancer of Xinjiang Uyghur women

目的探讨人乳头瘤状病毒（HPV）在新疆南部维吾尔族妇女宫颈癌患者的型别分布情况，为开发适宜该地区的HPV疫苗提供一定的理论依据。方法收集2008年6月至2010年4月就诊于新疆维吾尔自治区人民医院妇科的经病理确诊的新疆南部地区维吾尔族妇女宫颈癌患者120例，利用聚合酶链反应（PCR）和基因芯片技术检测HPVDNA并分型。结果120例宫颈癌患者中有115例为HPV感染，HPV总感染率为95．8％（115／120），其中HPV-16检出率最高为69．6％（80／115），其他高危型的感染率从高到低依次为HPV-6、-33、-18、45、38、-51、-59、-31、-52、-39、-68、-73，其他低危型的感染率从高到低依次为HPV-11、42、43、-6，而HPV-35、33、石6、-83、-MM4、—44未检测到。HPV-16单一感染率为53．9％（62／115），HPV-56单一感染率为17．4（20／115），混合感染率为29．6％（34／115）。结论新疆维吾尔族妇女宫颈癌患者中以HPV-16感染为主，HPV-56可能是新疆维吾尔族妇女宫颈癌较易感染的类型，体现了新疆维吾尔族妇女宫颈癌感染HPV的特殊性，开发适宜的HPV疫苗需进一步深入研究。

Objective To investigate the distribution of types of human papillomavirus （HPV） in cervical cancer Xinjiang Uyghur women. Methods From june 2008 to April 2010,patients in the gynecological departmen of people＇s Hospital of Xinjiang Uygur Autonomous Region ,who was gidiagnosed cervical cancer and came from southern of Xinjiang. Cervical cells of these patients were collected, HPV genotyping DNA chip was used to detect HP-DNA of each collected sample. Results Totally 120 wommen were screened,the infecton rationof HPV was 95.8% （ 115/120 ）. The positive rate of HPV-16 infection was 69.6% （ 80/115 ） ; other highrisk HPV infection rates were ranked from high to low as HPV-56, HPV-33, HPV-18, HPV-45, HPV-58, HPV-51,HPV-59, HPV-31, HPV-52, HPV-39, HPV-68, HPV-73, low-risk HPV infection rates were ranked from high to low as HPV-11, HPV-42, HPV-43, HPV-6. However, HPV-35, HPV-53, HPV-66, HPV83, HPV- MM4 and HPV-44 were not detected. Single infection of HPV16 or HPV56 was 53.9% （62/115） and 17.4 （20/115 ） respectively, ultiple infection rate was 29.6% （34/115 ）. Conclusion HPV-16 is the most common types in cervical cancer of Xinjiang Uyghur women. HPV56 maybe susceptible to the Xinjiang Uyghur women, reflecting the specificity of HPV infection in cervical cancer of Xinjiang Uygur women. It needs deep study to development a suitable HPV vaccines.