^(131)Ⅰ治疗Graves病患者医院感染相关因素分析及对策

Related factors and strategies for nosocomial infections of ^(131)Ⅰ treatment to graves disease

目的探讨^(131)Ⅰ治疗Graves病医院感染相关因素及对策。方法对2006年1月-2009年12月收治的922例接受^(131)Ⅰ治疗的Graves病患者进行回顾性调查分析。结果 922例中77例发生医院感染,总感染率8.35%;男性感染率为6.00%,女性感染率为9.00%,差异有统计学意义(P<0.05);育龄期妇女感染率10.04%,绝经后期(50~60岁)女性感染率5.19%,差异有统计学意义(P<0.01);感染与甲状腺激素水平无关,差异无统计学意义;4年中总感染率呈逐年下降趋势,感染部位以上呼吸道为主,占85.71%。结论应采取更积极的防治措施以降低^(131)Ⅰ治疗Graves病医院感染率,建议育龄期妇女行131I治疗时应避开月经期。

OBJECTIVE To investigate the related factors and strategies for nosocomiai infections of Graves disease treated with ^131I. METHODS A total of 922 hospitalized cases of Graves disease treated with ^131I were studied retrospectively from Jan 2006 to Dec 2009. RESULTS There were 77 cases of nosocomial infections in 922 cases, the total rate of nosocomial infections was 8. 35%, of the male 6.00% of the female 9.00% （P〈0. 05）. The women of child-bearing age was 10.04% ;the menopause women （aged from 50 to 60） was 5.19% （P〈0.01）. Infection was unrelated to thyroid hormone level. In the 4 years, the rate of nosocomial infections was decreased year by year. The foremost infection site was upper respiratory tract. CONCLUSION The results supports that more positive measures should be taken to decrease the nosocomial infections rate,and women of child-bearing age should avoid n21 treatment in menstrual period.