皮肤及软组织化脓性金黄色葡萄球菌感染的耐药谱分析

Drug resistant spectrum of staphylococcus aureus causing skin infection and soft tissue purulent infection

目的调查引起皮肤和软组织化脓性感染金黄色葡萄球菌的耐药性。方法应用VITEK-60全自动微生物分析仪进行药敏试验,对其耐药谱情况及临床特点进行分析。结果分离得到引起皮肤软组织化脓性感染金黄色葡萄球菌76株,其中耐甲氧西林金黄色葡萄球菌(MRSA)43株,占56.6%;在MRSA中,对青霉素、氨苄西林的耐药率为100.0%,红霉素为95.3%;在MSSA中对3种药物的耐药率分别为97.0%、54.5%、60.6%,对已做呋喃妥因药敏检测的菌株均为敏感株,未检到耐药菌株及中介菌株,万古霉素的耐药率均为0,亦未检到中介菌株。结论引起皮肤和软组织化脓性感染的金黄色葡萄球菌,对多种抗菌药物耐药率较高,大部分MRSA为多药耐药菌株,临床应长期进行耐药性监测。

OBJECTIVE To survey the bacterial resistance of the clinical isolates of Staphylococcus aureus causing skin and soft tissue infections. METHODS The antibiotic resistance was determined by Kirby-Bauer agar diffusion, and the clinical data of the strains was analyzed. RESULTS A total of 43 strains of MRSA, accounting for 56.6%, were included in 76 strains of S. aureus causing skin and soft tissue infections. Among methicillin-resistance S. aureus （MRSA）, the resistance rates to penicillin, ampicillin and erythromycin were 100. 0%, 100. 0% and 95.3% respectively, while the drug resistant rates of MSSA were 97%, 54. 4% and 60. 6% respectively. All strains were sensitive to vancomycin and nitrofurantoin, and intermediary strain was not found. CONCLUSION S. aureus causing skin and soft tissue infections are highly resistant to many kinds of antibiotic, and most of MRSA are multi drug resistant strains. The surveillance of MRSA in clinic should be strengthened.