泌尿生殖道支原体属与衣原体属感染现状及耐药分析

Status quo and resistance analysis of mycoplasma and chlamydia infection in genitourinary tract

目的了解泌尿生殖道支原体属、衣原体属感染现状及支原体属耐药谱,指导临床合理使用抗菌药物。方法采用培养法进行支原体属鉴定、半定量计数和药敏试验;胶体金法检测衣原体。结果 1600例患者中检出解脲脲支原体(Uu)感染750例(46.88%),人支原体(Mh)感染10例(0.63%),Uu+Mh混合感染71例(4.44%),总检出率为51.94%(831例);男女性别阳性率分别为44.6%、56.7%;1600例中同时检测沙眼衣原体(Ct)的982例标本共检出沙眼衣原体198株,检出率为20.16%,支原体属、衣原体属双重(或三重)感染率为11.1%(109例),其中Ct+Uu双重感染率为10.39%(102例),Ct+Mh双重感染率为0.20%(2例),Ct+Uu+Mh三重感染率为0.51%(5例);支原体属总药敏趋势显示,交沙霉素、米诺霉素、多西环素有较高的抑菌能力。结论永州地区支原体属感染率高于衣原体属;支原体属、衣原体属双重(或三重)感染率较高;支原体属以Uu感染为主;Mh多以Uu+Mh混合感染模式存在,且对喹诺酮类、红霉素类药物的耐药率极高,应引起临床医师高度重视。

OBJECTIVE To understand the drug resistance rate and status quo of mycoplasma and chlamydia infection in genitourinary tract. METHODS Mycoplasma culture was used to the identification, semi-quantitative assessment and susceptibility test. Immunogold filtration assay was used to detect chlamydia. RESULTS Among the 1600 samples, 831 were positive （51.94%）, composed of Uu 750 （46.88%）, Mh 10 （0.63%）, Uu＋Mh 71 （4.44%）. 982 samples were tested for chlamydia trachomatis, while 198 among them were proved positive （20.16%）. mycoplasma and chlamydia mixed infection 109 （11. 1%）, which were composed by Ct＋Uu 102 （10.39%）, Ct＋ Mh 2 （0.20%）, Ct＋Uu＋Mh 5（0.51%）. Most of the pathogen were seusitive to josamycin, minoeycline and doxyeycline. CONCLUSIONS Mycoplasma infection rate is higher than chlamydia in this area, The mixed infection of mycoplasma and chlamydia is common. Ureaplasma urealyticum is the mainly mycoplasma infection. Mh mostly exist in Uu＋Mh mixed infection mode, and the resistant rate of Mh to quinolones and erythromycin is extremely high. Doctors should pay more attention to these features.