控制钛表面生物活性磷灰石多晶核分布的研究

Study on controlling the distribution of bioactive apatite polycrystalline nucleuses on titanium surface

为了加速钛种植体与骨组织直接实现骨整合的速度,采用表面物理和化学方法处理钛基片,通过控制其在模拟体液中的表面矿化过程,获得适当密度的磷灰石多晶核。用SEM观察磷灰石多晶核的表面形貌和大小,对晶粒平均粒径和间距进行统计;用精密酸度计检测模拟体液的pH值;同时,讨论磷灰石多晶核的形成条件和过程。结果表明,通过控制钛表面粗糙度、氢氧化钠溶液浓度、浸泡的时间,可以在钛表面制备一定密度分布的磷灰石多晶核,且多晶核间距小于骨细胞线度(10～30μm)。

In order to accelerate the osseointegration speed between titanium implant and bone tissue,titanium substrates were treated by physical and chemical methods.The treated titanium substrates were immersed in a simulated body fluid（SBF） and proper density apatite polycrystalline nucleuses were formed by controlling mineralization process.The apatite polycrystalline nucleuses were observed by scanning electron microscope（SEM） to investigate surface morphology and size.Average grain size and space between grains were statistical.The pH value of simulated body fluid（SBF） was measured by precise acidimeter.Also formation condition and process were discussed.The results have verified certain distribution of apatite polycrystalline nucleuses,between which space between of grains is less than osteocytes dimension（10-30μm）,were prepared on titanium surface by controlling titanium surface roughness and sodium hydroxide concentration and immersion time.