摘要
胆囊癌不易早期诊断,预后差,其发病机制尚不明确。胆囊结石病与胆囊癌的发生具有一定相关性,胆石通过胆囊黏膜的机械性刺激、细菌感染、胆汁中的毒素等因素诱发胆囊黏膜癌变。胆石病相关的易感基因与胆囊癌发生也具有相关性。合理处理胆石病,是预防胆囊癌发生的重要措施。
Gallbladder carcinoma is difficult to be early diagnosed leading to poor prognosis. The pathogenesis of gallbladder carcinoma is not clear. Cholelithiasis is shown to be associated with gallbladder carcinoma. Mechanieal irritation, bacterial infection, xenobiotic in the bile may induce the carcinogenesis of gallbladder epithelium. Several risk genes associated with gallstone disease are also shown to be related with gallbladder carcinoma. Proper treatment of gallstone disease may provide a protective role in prevention of gallbladder carcinoma.
出处
《中国实用外科杂志》
CSCD
北大核心
2011年第3期202-204,共3页
Chinese Journal of Practical Surgery
关键词
胆囊癌
胆囊结石
危险因素
胆固醇
gallbladder carcinoma
cholelithiasis
risk factors
cholesterol
