摘要
目的探讨绝经女性血清瘦素与代谢综合征(MS)关系。方法对沈阳市某社区106名绝经女性进行人体测量、血清瘦素及MS指标测定。结果因子分析抽出2个公因子,累计方差贡献率为60.7%;核心因子为瘦素-体脂肪,包括瘦素、体脂肪含量、体质指数、腰围;另一因子为MS因子,包括腰围、血压、空腹血糖、甘油三酯、高密度脂蛋白胆固醇。体脂肪含量和收缩压是预测瘦素的独立变量(R2=0.607,P〈0.01);瘦素浓度随MS成分数的增多而升高,MS≥3项组瘦素浓度为(11.33±4.51)ng/mL、2项组为(9.21±4.70)ng/mL,均高于≤1项组的(5.54±3.46)ng/mL(均P〈0.05);高瘦素水平组(〉9.2 ng/mL)MS的危险度是低瘦素水平组(≤9.2 ng/mL)的4倍(OR=4.00,95%CI=1.34~11.97,P〈0.05)。结论绝经女性瘦素与体脂肪含量、收缩压呈正相关,高瘦素水平可增大MS的危险度。
Objective To evaluate the relationship between serum leptin and metabolic syndrome(MS) in postmenopausal women.Methods Anthropometry,serum leptin and parameters related to MS were measured among 106 postmenopausal women in a local community in Shenyang.Results Factor analysis revealed two factors explaining 60.7% of the total variance.The key factors associated with leptin and body fat components included leptin,body fat percentage,body mass index,and waist circumference;the other factors were characterized by MS components,including waist circumference,blood pressure,fasting glucose,triglyceride,and high-density lipoprotein cholesterol.Body fat percentage and systolic blood pressure were independent variables for predicting serum leptin(R2=0.607,P0.01).Serum leptin in the subjects increased with the number of MS components,and leptin levels in the subjects with more than three components(11.33±4.51 ng/mL) and two components(9.21±4.70 ng/mL) were significantly higher than those of with no more than one component(5.54±3.46 ng/mL)(all P0.05).Risk of MS for the subjects with the high leptin level(9.2 ng/mL) was four times higher than those of with low eptin(≤9.2 ng/mL)(odds ratio=4.00,95% confidence interval:1.34-11.97;P0.05).Conclusion Serum leptin positively correlates with body fat percentage and systolic blood pressure and higher leptin level increases the risk of MS in postmenopausal women.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2011年第3期280-281,共2页
Chinese Journal of Public Health
基金
辽宁省教育厅高等学校科研项目(2009B172)