绝经女性血清瘦素水平与代谢综合征关系

Relationship between serum leptin and metabolic syndrome in postmenopausal women

目的探讨绝经女性血清瘦素与代谢综合征（MS）关系。方法对沈阳市某社区106名绝经女性进行人体测量、血清瘦素及MS指标测定。结果因子分析抽出2个公因子,累计方差贡献率为60.7%;核心因子为瘦素-体脂肪,包括瘦素、体脂肪含量、体质指数、腰围;另一因子为MS因子,包括腰围、血压、空腹血糖、甘油三酯、高密度脂蛋白胆固醇。体脂肪含量和收缩压是预测瘦素的独立变量（R2=0.607,P〈0.01）;瘦素浓度随MS成分数的增多而升高,MS≥3项组瘦素浓度为（11.33±4.51）ng/mL、2项组为（9.21±4.70）ng/mL,均高于≤1项组的（5.54±3.46）ng/mL（均P〈0.05）;高瘦素水平组（〉9.2 ng/mL）MS的危险度是低瘦素水平组（≤9.2 ng/mL）的4倍（OR=4.00,95%CI=1.34~11.97,P〈0.05）。结论绝经女性瘦素与体脂肪含量、收缩压呈正相关,高瘦素水平可增大MS的危险度。

Objective To evaluate the relationship between serum leptin and metabolic syndrome（MS） in postmenopausal women.Methods Anthropometry,serum leptin and parameters related to MS were measured among 106 postmenopausal women in a local community in Shenyang.Results Factor analysis revealed two factors explaining 60.7% of the total variance.The key factors associated with leptin and body fat components included leptin,body fat percentage,body mass index,and waist circumference;the other factors were characterized by MS components,including waist circumference,blood pressure,fasting glucose,triglyceride,and high-density lipoprotein cholesterol.Body fat percentage and systolic blood pressure were independent variables for predicting serum leptin（R2=0.607,P0.01）.Serum leptin in the subjects increased with the number of MS components,and leptin levels in the subjects with more than three components（11.33±4.51 ng/mL） and two components（9.21±4.70 ng/mL） were significantly higher than those of with no more than one component（5.54±3.46 ng/mL）（all P0.05）.Risk of MS for the subjects with the high leptin level（9.2 ng/mL） was four times higher than those of with low eptin（≤9.2 ng/mL）（odds ratio=4.00,95% confidence interval：1.34-11.97;P0.05）.Conclusion Serum leptin positively correlates with body fat percentage and systolic blood pressure and higher leptin level increases the risk of MS in postmenopausal women.