老年血压正常高值者中心动脉压与颈动脉内膜中层厚度的相关研究

Relationship between central blood pressure and carotid intima-media thickness in prehypertensive old participants

目的探讨血压正常高值者中心动脉压与颈动脉内膜中层厚度(IMT)的关系。方法选择健康体检人群346例,根据血压将患者分为理想血压组151例(血压<120/80 mm Hg,1mm Hg=0.133 kPa)和血压正常高值组195例(血压120～139/80～89 mm Hg),应用大动脉测量仪测量入选者中心动脉压;应用颈动脉超声测量颈动脉IMT。结果血压正常高值组中心动脉收缩压、舒张压、脉压、平均收缩压、平均舒张压、收缩末压及IMT均高于理想血压组(P<0.01);中心动脉增强压及增强指数高于理想血压组(P<0.05)。中心动脉收缩压和脉压是IMT的影响因素(β=0.344,0.296,P<0.05)。结论血压正常高值者的中心动脉压和颈动脉IMT已增加,中心动脉收缩压和脉压是影响颈动脉IMT的主要因素。

Objective To investigate the relationship between central blood pressure and carotid intima-media thickness （IMT） in prehypertensive participants. Methods According to the blood pressure level,346 individuals were divided into two groups, namely, normotensive controls 151 cases,prehypertensive participants 195 cases. Central blood pressure was measured noninvasively using SphygmoCor device,and carotid IMT was measured by ultrasonography. Results Central systolic blood pressure（CSP）, central diastolic blood pressure, central pulse pressure（CPP）, central mean systolic blood pressure, central mean diastolic blood pressure, central end systolic blood pressure and carotid IMT were higher in prehypertensives than in normotensives （P 〈 0.01）. Central arterial augmentation pressure and augmentation index were higher in prehypertensives than in normotensives （P〈 0.05）. Multiple linear regression showed that CPP and CSP were risk factors for IMT（β= 0. 344,0. 296, P 〈 0.05）. Conclusion Central aortic pressure and carotid IMT in prehypertensive participants have already increased, CSP and CPP were the most important influential factors of carotid IMT.