β-内酰胺类抗生素及其复合制剂使用的因素分析

Analysis of Using Factors for β-lactams and Co-β-lactamase Inhibitor Antibiotics

目的:分析苏州市某中医医院β-内酰胺类抗生素及其复合制剂的临床使用的相关因素,为临床合理使用此类药物提供参考。方法:采用回顾性分析,统计2005年—2009年该院β-内酰胺类抗生素及其复合制剂使用的品种、规格、剂型、销售数量和总金额,对金额排序和用药频度(DDDs)进行相关分析。结果:β-内酰胺类抗生素占抗生素总金额的比例逐年增长,2008年达62.48%;β-内酰胺/β-内酰胺酶抑制剂复合抗生素的总消耗金额比例则先增后减,2008年起呈明显下降趋势;两者金额比值由0.42降至0.13。2005年—2009年β-内酰胺/β-内酰胺酶抑制剂复合抗生素的品种数在β-内酰胺类抗生素及其复合制剂金额进入该年度前10位的药物中分别有4,3,3,2,1种;在DDDs进入该年度前10位分别有3,2,2,1,1种。结论:该中医院β-内酰胺/β-内酰胺酶抑制剂复合抗生素应用存在不合理现象,应加强抗生素的监管及用药前的药敏监测以减少抗生素不合理使用。

Objective：To analyze using factor for β-lactams antibiotics and co-β-lactamase inhibitor antibiotics in certain hospitals of TCM in Suzhou,and to provide the reference of this kind of medicines for clinic.Methods： A review statistics was used on the data of variety,specifications,forms,the total consumption amount and the total consumption sum in this hospital during 2005~2009,then ranking of amount of money and DDDs were analysed relevantly.Results： The ratio of β-lactams antibiotics to the total antibiotics increased each year,expecially increased by 62.48% in 2008;but the ratio of co-β-lactamase inhibitor antibiotics to the total antibiotics incresased first and decreased later,and it decreased obviously in 2008.The proportion of the upper two groups decreased from 0.42 to 0.13.The amount of co-β-lactamase inhibitor antibiotics were 4,3,3,2,1 in the top 10 places on the list of total consumption sum respectively from 2005 to 2009,which were 4,3,3,2,1 in the top 10 places on the list of DDDs appropriately.Conclusion： There is irrational use of β-lactams antibiotics/co-β-lactamase inhibitor antibiotics,and it is important to enhance antibiotics supervision and drug sensitivity before use for decreasing the abuse of antibiotics.