老年2型糖尿病与血清趋化素、高敏C反应蛋白间以及与各血液指标的关系

The Relationships between Serum Chemerin and High-sensitivity C-reactive Protein (hs-CRP) Levels in Elderly Patients with Type 2 Diabetes

目的探讨老年2型糖尿病(T2DM),糖尿病伴高血压患者和正常人血清趋化素(chemerin)与高敏C反应蛋白(high-sensitivity CRP,hs-CRP)水平之间以及与各检测指标的关系。方法受试者分为3组,52例单纯2型糖尿病(DM组),54例2型糖尿病合并高血压者(DMG组)和52例健康的60岁以上老年人(正常对照,NC组),观察指标有腰围(WC)、收缩压(SBP)、舒张压(DBP)、体质指数(BMI)、血清chemerin、hs-CRP、空腹血糖(FPG)、外周血白细胞(WBC)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等进行组间比较,并比较了血清chemerin、hs-CRP以及与其他指标的相关关系。结果 DMG组、DM组的BMI、WC、chemerin、hs-CRP、TC、TG、LDL-C、FPG均高于NC组(P<0.05);与DM组相比,DMG组chemerin、hs-CRP、FPG、TC、LDL-C增高(P<0.05)。血清chemerin和hs-CRP呈正相关(r=0.694,P<0.01)。血清chemerin、hs-CRP与TG、TC、LDL-C、FPG、BMI、WC、SBP、DBP呈正相关(P<0.05)。结论 伴有高血压的老年2型糖尿病患者chemerin和hs-CRP高于单纯老年2型糖尿病患者,对chemerin和hs-CRP同时检测并进行联合分析,为寻找预防和治疗肥胖、2型糖尿病及高血压提供新的治疗方向。

Objective To explore the relationships between serura chemerin and high-sensitivity C-reactive protein （hs-CRP） levels in elderly patients with type 2 diabetes. Methods All of subjects were more than 60 years old and were divided into three groups： 52 diabetic patients with normal blood pressure （DM group）, 54 diabetie patients with hypertension （DMG group）, and 52 heahhy as control （NC group）. The serum chemerin, hs-CRP, FPG, WBC, TG, TC, HDL-C and LDL-C were assayed, and the BMI, WC, SBP and DBP were determined among three groups. Results The levels of ehemerin, hs-CRP, TG, LDL-C, FPG, BMI, WC, SBP, DBP and TC in the DMG and DM group were significantly higher than that in NC group （all P〈0.05）; levels of ehemerin, hs-CRP and FPG, TC, LDL-C in DMG group were significantly higlaer than those in DM group （P〈0.05）. Serum eheme6n was positive correlated with hs-CRP （r=0.694, P〈0.01）. Conclusion Chemerin and Hs-CRP maybe the important predicator for the complication of hypertension in elderly patients with type 2 diabetes mellitus.