摘要
目的比较文拉法辛缓释剂(博乐欣)与阿米替林对老年抑郁症的治疗效果。方法将80例老年抑郁症患者按住院顺序分为两组,分别给予博乐欣和阿米替林进行为期8周的治疗,治疗结束后进行1年的随访。用汉密尔顿抑郁量表(HAM D)、抗抑郁药副反应量表(SERS)于治疗前、治疗中和出院后1年对患者进行疗效评估。结果治疗结束后两组显效率分别为75%和68.4%、有效率分别为97.5%和94.7%,两组比较P>0.05;治疗2周后博乐欣组和阿米替林组的HAM D分分别为22.4±2.8和26.7±3.2,P<0.05;治疗结束时两组SERS分分别为1.7±0.3和4.5±1.9,P<0.01;出院1年后博乐欣组8例复发,阿米替林组15例复发,两者有显著差异(χ2=5.5,P<0.05)。结论博乐欣是一种安全、有效的抗抑郁剂,比较适用于老年抑郁症患者。
Objective To evaluate the effects of Venlafaxine（Bolexin） and Amitriptyline in treatment of elderly depression.Methods A total of 80 cases of elderly hospitalized patients with depression were divided into two groups in turn for 8 weeks of treatment with Venlafaxine and Amitriptyline.After treatment,1 year of follow-up was conducted.The effects were assessed with the Hamilton Depression Scale（HAMD） and Side Effects Antidepressant Scale（SERS） before treatment,when treatment,and in 1 year after discharge.Results At the end of treatment,the significantly effective rates of the two groups were 75% and 68.4% respectively,the effective rates were 97.5% and 94.7% respectively（P〉0.05）;two weeks after treatment,HAMD points of Venlafaxine group and amitriptyline group were（22.4±2.8） and（26.7±3.2） respectively（P〈0.05）;At the end of the treatment,the SERS points of the two groups were（1.7±0.3） and（4.5±1.9） respectively（P〈0.01）;After one year of discharge,8 cases of venlafaxine group and 15 cases of Amitriptyline group relapsed,there was significant differences（χ2=5.5,P〈 0.05）.Conclusion Bolexin is a safe and effective antidepressant,is applicable to elderly depression.
出处
《中国健康心理学杂志》
2011年第1期12-13,共2页
China Journal of Health Psychology
