ACTN3基因R577X多态性与运动能力的关联性研究:Meta分析

Association of ACTN3 Gene R577X Polymorphism and Athletic Performance:A Meta-Analysis

目的：采用Meta分析定量评价ACTN3基因R577 X多态性与耐力素质和速度力量素质的相关性;方法：以耐力型项目运动员组和对照组的XX/（RR＋RX）OR、X/R OR和速度力量型项目运动员组和对照组的RR/（RX＋XX）OR、R/X OR值为统计量,检索截止至2010年11月的相关文献,制定文献筛选标准,对纳入研究进行异质性检验,数据合并和发表偏倚检验;结果：涉及耐力型项目研究11项和力量速度型项目研究10项分别纳入meta分析,其中,耐力型项目研究共包含运动员组2 220例和对照组3 410例,力量速度型项目研究共包含运动员组1 140例和对照组2 800例。速度力量型项目RR/（RX＋RR）OR=1.40（95%CI=1.21~1.62,P〈0.01）,R/X OR=1.33（95%CI=1.20~1.48,P〈0.01）,亚组分析欧裔人群RR/（RX＋RR）OR=1.37（95%CI=1.17~1.60,P〈0.01）;R/X OR=1.37（95%CI=1.22~1.53,P〈0.01）,Egger’s检验和Begg’s检验均未发现显著发表偏倚;结论：ACTN3基因R577 X多态性存在种族差异,RR基因型和R等位基因是速度力量素质的保护因素。欧裔人群中,RR基因型和R等位基因与速度力量素质显著关联。ACTN3基因R577 X多态性可以作为速度力量型项目运动员基因选材的候选位点之一,但用于耐力型项目运动员的基因选材尚证据不足。

Objective：To investigate the association between α-actinin-3（ACTN3） gene R577X polymorphism and athletic performance by meta analysis.Method：Search related literature before Oct.2010 and identify including and excluding criteria,odds ratios of XX/（RR＋RX） and X/R between endurance athletes and controls,RR/（RX＋XX） and R/X between sprint/power athletes and controls also were selected,then heterogeneity test,data merge,regression analysis for heterogeneity and publication bias were done.Result：11 studies were related to endurance events including 2 220 athletes and 3 410 controls,whereas 10 studies were related to sprint / power events including 1 140 athletes and 2 800 controls.In sprint/power events,RR/（RX＋XX） OR and R/X OR were 1.40（95% CI=1.21~1.62,P0.01） and 1.33（95%CI=1.20~1.48,P0.01）,respectively.Sub-category analysis showed RR/（RX＋XX） OR and R/X OR were 1.37（95%CI=1.17~1.60,P0.01） and 1.37（95%CI=1.22~1.53,P0.01） in Europeans,respectively.Both Egger＇s and Begg＇s test revealed that there were no significant publication bias found.Conclusion：In addition to racial diversity of genotype frequency and allele frequency distribution,RR genotype and R allele are regarded as protective factors of speed/power performance.RR genotype and R allele were association with elite speed/power performance in Europeans.ACTN3 gene R577X polymorphism could be one of the candidate gene sites in talent identification of speed/power events,whereas it lacked sufficient evidence for application in endurance events.