多杀性巴氏杆菌病研究进展

Progress of Multocida Pasteurellosis

多杀性巴氏杆菌(P.multocida)是引起多种畜禽巴氏杆菌病(pasteurellosis)的病原菌,主要引起动物发生出血性败血病或传染性肺炎。动物之间相互传染,人被动物咬伤可感染。畜禽巴氏杆菌病的防治主要使用多杀性巴氏杆菌疫苗.目前防制巴氏杆菌病的疫苗主要有强毒灭活菌苗、弱毒菌苗和亚单位疫苗,这些疫苗在一定程度上对巴氏杆菌病的防治起到了一定的作用,但由于多杀性巴氏杆菌的血清型多,免疫效果也不理想,有关巴氏杆菌病防治还有待进一步研究。本文就多杀性巴氏杆菌的毒力因子、免疫原等进行综合阐述。

Pasteurella multocida is a kind of pathogen,which can cause a lot of livestock and poultry pasteurellosis,mainly infectious hemorrhagic septicemia or pneumonia,the disease can transmit between animal,people also can be infected after being bitten.Pasteurella multocida vaccine is the key method to prevention and treatment of livestock and poultry pasteurellosis.At present,the vaccines preventing pasteurellosis include virulent inactivate strain,attenuated strain and subunit vaccine,these vaccines work well on pasteurellosis to some extent,however,due to different serotypes of pasteurella multocida,the immunization effect is not well,so further studies are needed on this problem.This article discussed virulence factors and immunogen of pasteurellosis.