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细胞视黄酸结合蛋白与肿瘤相关研究 被引量：5

Research progress of CRABP and cancers
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摘要 细胞视黄酸结合蛋白(CRABP)在细胞质介导视黄酸与细胞核上视黄酸核受体之间互相作用,同时促进视黄酸代谢酶类的活性,增强视黄酸的转化速率。在脊椎动物细胞中,CRABP包含两种高度同源蛋白质:CRABP1和CRABP2。CRABP属于低分子量的蛋白质,种属间高度保守。现有研究表明在许多肿瘤中存在CRABP基因异常甲基化,基因表达水平较正常组织有差别;CRABP基因异常甲基化与部分肿瘤患者低生存率存在相关性,CRABP基因可以成为常见的肿瘤诊断以及判断预后的分子靶标。 Cellular retinoic acid-binding protein （CRABP） belongs to the family of intracellular lipid-binding proteins and is involved in RA metabolism and RA metabolizing enzymes activity. CRABP appears in vertebrate organisms in two isoforms, CRABP1 and 2, with distinct distribution and functions. CRABP is frequently hypermethylated in many carcinomas, so CRABP gene has a potential as a diagnostic and prognostic marker in many cancers.
作者 杨芳
机构地区 安康学院农学与生命科学学院
出处 《生命的化学》 CAS CSCD 北大核心 2011年第1期68-71,共4页 Chemistry of Life
基金 陕西省教育厅自然科学基金项目(08JK210) 安康学院高层次人才科研专项(AYQDZR200805)资助
关键词 视黄酸结合蛋白 甲基化 肿瘤 分子靶标 CRABP methylation carcinoma diagnostic and prognostic marker
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献24

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二级参考文献30

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共引文献3

同被引文献60

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  • 3张立凤,桂永浩,钟涛,王跃祥,蒋球,崇梅,孙淑娜,宋后燕.视黄酸影响斑马鱼胚胎心脏房室分化[J].复旦学报（医学版）,2007,34(1):88-91. 被引量：7
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引证文献5

二级引证文献15

生命的化学
2011年 第1期

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