摘要
钙调蛋白激酶Ⅱ(CaMKⅡ)是一种多功能蛋白激酶,作为细胞钙信号的重要响应分子广泛参与细胞生理功能调节,包括细胞形态、凋亡、迁移、兴奋-收缩偶联和骨重建等。本文在介绍CaMKⅡ分子结构及其活化机制的基础上,就其对细胞生理功能的调节作用作一综述。
Calcium/calmodulin-dependent protein kinase Ⅱ （CaMKII） is a multifunctional Ser/Thr protein kinase. As an important molecule response to calcium signal, CaMKII is widely involved in regulating cellular physiological functions. In this paper, the structure and regulation of CaMKII activity were briefly introduced. In addition, this paper reviewed the roles of CaMKII in cell morphology, apoptosis, cell migration, excitation-contraction coupling and bone remodeling.
出处
《生命的化学》
CAS
CSCD
北大核心
2011年第1期95-101,共7页
Chemistry of Life
基金
国家自然科学基金(No.30800203)资助
