分散液相微萃取技术及其在生物样品分析中的应用进展

Dispersive liquid-liquid microextraction and its application in analysis of biological samples

分散液相微萃取技术(dispersive liquid-liquid microextraction,DLLME)是一种新型样品前处理技术,具有操作简便、快速、有较高的富集因子、萃取剂使用量少的优点,与其他样品前处理技术比较,最大的优势是萃取时间短。该技术已应用于环境样品、生物样品、食品样品等领域的处理中。本文根据DLLME的基本原理与步骤、主要的影响因素以及该技术在生物样品中的应用等方面进行综述,为包括DLLME在内的液相微萃取技术研究提供参考。

Dispersive liquid-liquid microextraction（DLLME） is a new sample preparation technique,which is easy and fast in operation.It has a higher enrichment factor and consumes less volume of organic solvent.The most attractive merit of DLLME is that extraction time is quite shorter than other sample preparation methods.The technique has been applied to prepare environmental samples,biological samples,food samples and others.In this paper,we summarized the basic principle and procedure of DLLME,major influencing factors and recent applications of this technique in biological samples,which might provide reference for further study on liquid-liquid microextraction.