TACE联合复方苦参注射液治疗中晚期原发性肝癌的疗效观察

Therapeutic Effect of TACE Combined with Compound Sophora flavescens Injection in Mid and Advanced Stage Primary Liver Cancer

目的:观察经皮选择性肝动脉化疗栓塞术(TACE)联合复方苦参注射液治疗中、晚期原发性肝癌的临床疗效。方法:将64例原发性肝癌患者随机分为单纯TACE组(32例)和TACE联合复方苦参注射液组(32例),分析比较2组患者治疗前、后甲胎蛋白含量、肿瘤大小、Child-pugh分级、MELD评分及生活质量KPS评分的变化,跟踪随访患者生存期,比较2组的治疗效果。结果:TACE联合复方苦参注射液组临床疗效各方面均优于单纯TACE组(P<0.05),TACE联合复方苦参注射液组患者生存期高于单纯TACE组(P<0.05);TACE联合复方苦参组治疗后KPS评分升高幅度高于单纯TACE组(P<0.05);TACE联合复方苦参注射液组治疗后MELD评分、Child-pugh评分降低幅度均大于单纯TACE组(P<0.05);TACE联合复方苦参注射液组术后甲胎蛋白降低及肿瘤体积的减小比单纯TACE组明显(P<0.05)。TACE联合复方苦参注射液组治疗过程中未见严重不良反应。结论:TACE联合复方苦参注射液治疗原发性肝癌的临床疗效显著,可以减少TACE术后不良反应的发生。

To observe the clinical therapeutic effect of the percutaneous selective hepatic artery chemoembolization （TACE） combined with compound Sohpora flavesces injections in mid and advanced stage primary liver cancer. METHODS： 64 patients with primary liver cancer were randomly divided into simple TACE treatment group （32 cases） and TACE combined with compound S.flavescens injection treatment group （32 cases）, AFP content, tumor size, Child-pugh classification, MELD score and quality of life changes in KPS of before and after treatment were compared, the survival of patients were followed up, the treatment effect of 2 groups were compared. RESULTS ： The clinical therapeutic effect of TACE combined with compound S.fla- vescens injection treatment group was all better than the simple TACE treatment group （P〈0.05） , The survival in patients of TACE combined with compound S.flavescens injection treatment group was higher （P〈0.05） ; After treatment, the KPS score was higher magnitude of TACE combined with compound S.flavescens injection treatment group were higher than the simple TACE treat- ment group （P〈0.05） ; After treatment, the MELD score and Child-pugh score were lower amplitude of TACE combined with compound S.flavescens injection treatment group was higher than the simple TACE treatment group （P〈0.05） ; After treatment, the reduce of AFP and the decrease of tumor volume of TACE combined with compound S.flavescens injection treatment group were evident than the simple TACE treatment group （P〈0.05）.During the treatment, TACE combined with compound S.flavescens injection treatment group have no serious side effects. CONCLUSION： TACE combined with compound S.fiavescens injection in treating pri- mary liver cancer have a significant effect and a good clinical value, has created a new future for the treatment of KEY WORDS