安宫牛黄丸对自发性高血压大鼠急性脑出血后脑水肿及神经功能缺损的影响

Effect of Angong Niuhuang Pills on cerebral edema and def icit of neurological function after acute intracerebral hemorrhage in spontaneously hypertension rats

目的:观察安宫牛黄丸对自发性高血压大鼠脑出血后脑组织含水量、脑系数以及神经功能缺损的影响。方法:将自发性高血压大鼠随机分为5组:空白对照组、模型组、西药治疗组、中药治疗组、中西药结合治疗组,于6、24、48、72h观察大鼠神经行为学评分,测量脑组织含水量与脑系数。结果:模型组大鼠脑组织含水量、脑系数及行为学评分较空白对照组高(P<0.05),3个治疗组脑组织含水量、脑系数及行为学评分低于模型组(P<0.05),中西结合治疗组脑组织含水量、脑系数及行为学评分明显低于中药治疗组及西药治疗组(P<0.05),中药治疗组与西药中药治疗组与西药治疗组间相比差异无显著性。结论:安宫牛黄丸能够有效减轻脑出血后脑组织含水量、减少脑系数并改善神经功能缺损症状。

Objective： To explore the effect of Angong Niuhuang Pills on the deficit of neurological function,the change of brain coefficient and and the brain water content in spontaneously hypertensive rats after acute intracerebral hemorrhage.Methods in this study,the spontaneously hypertensive rats were randomly divided into five groups： blank control group,model group,western medicine treated group.Chinese medicine treated group,integrated Chinese medicine and western medicine treated group.Observing the scale of neurological behaviors in rats at 6h,24h,48h and 72h,measuring brain water content and the change of brain coefficient.Results： the model group was significantly higher than the blank control group in the aspects of the brain water content,the change of brain coefficient.and the scale of neurological behaviors（P0.05）,but the three treated groups were lower than model group（P0.05）,the change of brain coefficient,the brain water content and the scales of behaviors in integrated Chinese medicine and western medicine treated group were significantly lower than Chinese medicine and Western medicine treated group（P0.05）,the differences between the comparison of Chinese medicine and Western medicine treated group were not significant.Conclusion： Angong Niuhuang Pills could alleviate cerebral edema,decreasing the brain coefficient after ICH and improve the symptoms of the deficit of neurological function.