摘要
目的探讨手术治疗精索静脉曲张(VC)对患者血清中抗精子抗体(ASAB)的影响。方法分析60例左侧Ⅱ°VC患者。20例作为观察对照(A组);20例行保留睾丸动脉的精索静脉高位结扎术(B组);20例行不保留睾丸动脉的精索静脉高位结扎术(C组)。酶联免疫法定量测定血清中抗精子抗体IgG、IgM含量。SPSS16.0软件进行统计学分析。结果三组术前IgM、IgG总体比较无统计学意义(F=0.59,P:0.5583;F=0.98,P=0.3808),术前IgM、IgG各组间两两比较均亦无统计学差异;三组术后IgM、IgG总体比较有统计学意义(F=29.47,P〈0.001;F=30.45,P〈0.001),且术后IgM、IgG各组间两两比较均有统计学意义,其中B组与C组IgM、IgG比较均有统计学意义(Q=3.1357,p〈0.05;Q=3.1733,p〈0.05)。A组前后ASAB水平变化无统计学意义(P〉0.05)。B、C两组术前术后ASAB水平差异均有显著性意义(P〈0.01)。结论左侧Ⅱ°VC患者经腹腔镜手术治疗后血清中ASAB水平降低,且保留睾丸动脉效果更佳。
Objectives To investigate the level of anti - sperm antibodies (ASAB) in the serum of the patient with varicocele (VC) before and 3 - 9 months after surgery. Methods 6o cases of patients with Ⅱ ° VC in left were chosen to measured serum ASAB in our study. 20 cases were observed as control group (A group) ; 20 cases were reserved the testicular artery in surgery ( B group) ; 20 cases didnl preserved the testicular artery in surgery ( C group). The level of ASAB in the serum ( IgM and IgG) were performed before and 39 months after surgery,as measured by ELISA in a quantitative way. The data were analyzed by SPSSI6.0 software. Results Before surgery, three groups of IgM, IgG were no statistically significant overall ( F = 0.59, p = 0. 5583 ; F = 0.98, p = 0. 3808 ), and there were no statistically significant between any 2 groups in lgM, IgG ; After surgery, three groups of IgM, IgG overall comparison were statistically significant ( F = 29.47, p 〈0. 001 ; F = 30.45, p 〈 0.001 ), the differences be- tween any 2 groups were statistically significant in IgM, IgG, In particular, the differences between B group and C group in IgM, IgG were statistically significant ( Q = 3.1357, p 〈 0.05 ; Q = 2.8271, p 〈 o. 05 ). In A group, AS- AB levels before surgery and after surgery showed no statistically significant ( all p 〉 0.05 ). In group B and C, preoperative and postoperative ASAB levels were differences, and the difference was statistically significant (all p 〈 0. 01 ). Conclusions Laparoscopic treatment of Ⅱ ° VC in left can decrease serum levels of ASAB,and preserve the testicular artery is more effective.
出处
《国际泌尿系统杂志》
2011年第2期158-160,共3页
International Journal of Urology and Nephrology