RRM RNA结合蛋白的结构与功能

RRM RNA Binding Protein: Structure and Function.

Ｒ Ｒ Ｍ Ｒ Ｎ Ａ 结合蛋白是一类含一个或数个 Ｒ Ｒ Ｍ 结构域及附属结构域的 Ｒ Ｎ Ａ 结合蛋白， 参与 Ｒ Ｎ Ａ 前体的剪接、 Ｒ Ｎ Ａ 的细胞定位、 Ｒ Ｎ Ａ 的稳定性等多种转录后调控过程． 在 Ｒ Ｒ Ｍ 基序中含有许多保守的氨基酸以保证对 Ｒ Ｎ Ａ 的结合活性， 但是这一家族的不同蛋白质却能特异地结合各种不同的 Ｒ Ｎ Ａ 分子． Ｒ Ｒ Ｍ Ｒ Ｎ Ａ

RRM RNA binding protein is a kind of RNA binding protein which contains one or more RNA recognition motifs and some affiliated motifs. It participates in genes post transcriptional regulations including splicing of pre mRNA, cellular localization and stability maintenance of RNA. Conservative amino acids in the RRM motif are essential for RNA binding, but the specific binding depends on other factors. Some RRM RNA binding proteins are related to genetic diseases and tumors.