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双相障碍与氧化应激损伤 被引量：11

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摘要 双相障碍（bipolar disorder，BPD）是一种高致残率的重性精神疾病，主要表现为躁狂相与抑郁相反复间歇交替或循环发作，患病率约为1％～1．5％。双相障碍病因复杂，迄今不明。流行病学调查显示双相障碍与心血管疾病、肥胖和糖尿病等躯体疾病的共病率较高，
作者 张晨 方贻儒
机构地区 上海交通大学医学院附属精神卫生中心
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2011年第2期122-124,共3页 Chinese Journal of Nervous and Mental Diseases
基金 国家自然科学基金(编号:81000581) 上海市自然科学基金(编号:10ZR1425700) 上海市卫生局青年科研基金(编号:2009Y051)
关键词 双相障碍 氧化应激 抗氧化酶 DNA损伤
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献20

  • 1Ronald C.Kessler,郭万军,曾卓谦,胡赤怡,刘肇瑞,黄悦勤,何燕玲,张明园,沈渔邨,李诚.世界精神卫生调查行动及其对中国精神障碍流行病学研究的提示[J].中国神经精神疾病杂志,2010,36(7):385-388. 被引量：38
  • 2Fleischhacker WW,Cetkovich-Bakmas M,De Hert M,et al.Comorbid somatic illnesses in patients with severe mental disorders:clinical,policy,and research challenges[J].J Clin Psychiatry,2008,69(4):514-519.
  • 3Dean OM,van den Buuse M,Bush AI,et al.A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice[J].Curr Med Chem,2009,16(23):2965-2976.
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  • 6Valvassori SS,Moretti M,Kauer-Sant'Anna M,et al.Effects of a gastrin-releasing peptide receptor antagonist on D-amphetamine-induced oxidative stress in the rat brain[J].J Neural Transm,2010,117(3):309-316.
  • 7Alsuwaidan MT,Kucyi A,Law CW,et al.Exercise and bipolar disorder:a review of neurobiological mediators[J].Neuromolecular Med,2009,11(4):328-336.
  • 8Andreazza AC,Kauer-Sant'anna M,Frey BN,et al.Oxidative stress markers in bipolar disorder:a meta-analysis[J].J Affect Disord,2008,111(2-3):135-144.
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  • 10Valvassori SS,Moretti M,Kauer-Sant'Anna M,et al.Effects of a gastrin-releasing peptide receptor antagonist on D-amphetamine-induced oxidative stress in the rat brain[J].J Neural Transm,2010,117(3)309-316.

二级参考文献81

  • 1McMahon FJ, Stine OC, Meyers DA, et al. Patterns of maternal transmission in bipolar affective disorder[ J]. Am J Hum Genet, 1995,56(6) : 1277 - 1286.
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  • 6Munakata K, Iwamoto K, Bundo M, et al, Mitochondfial DNA 3243A > G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia[J]. Biol Psychiatry, 2005, 57(5): 525-532.
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  • 8Kasahara T, Kubota M, Miyauchi T, et al. Mice with neuronspecific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes[ J]. Mol Psychiatry, 2006, 11 (6) : 577 - 593.
  • 9Munakata K, Tanaka M, Mori K, et al. Mitochondrial DNA 3644T→C mutation associated with bipolar disorder [ J ]. Genomies, 2004, 84(6) : 1041 - 1050.
  • 10Kazuno AA, Munakata K, Moil K, et al. Mitochondrial DNA haplogroup analysis in patients with bipolar disorder [ J ]. Am J Med Genet B Neuropsychiatr Genet, 2009, 150B(2) : 243 -247.

共引文献45

同被引文献80

引证文献11

二级引证文献66

中国神经精神疾病杂志
2011年 第2期

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