摘要
选择感染性噬菌体（ Ｓ Ｉ Ｐ） 技术是利用丝状噬菌体次要衣壳蛋白 ＰⅢ的分子结构组件， 并以噬菌体展示技术为基础发展而来． Ｓ Ｉ Ｐ 的技术关键在于使没有感染性的噬菌体颗粒必须严格依赖分子间的相互作用、结合而重获感染性， 已有的研究表明 Ｓ Ｉ Ｐ 技术可望成为一项获得相互作用分子对的极其有效和高度特异性的新技术，
The SIP technology is achieved by exploring the modular structure of minor coat protein Ⅲ of filamentous phage, and based on the technique of phage display. In SIP, the infectivity of an otherwise non infective phage particle is restored strictly upon the binding occurrence between interacting molecular partners. Some mechanistic dissection studies showed that SIP is a novel extremely effective and highly specific technique for identifying interacting molecular pairs, and it is very promising.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1999年第4期407-407,共1页
Progress In Biochemistry and Biophysics
关键词
选择
感生
噬菌体
分子间相互作用
技术
selectively infective phage,molecular interaction,technique
