经皮穿刺瘤内注射碘油化疗药物乳剂治疗兔移植性VX2瘤的疗效观察

Effect of percutaneous intratumoral injection of chemotherapic agents lipiodol emulsion on implanted VX2 tumor in rabbits

目的:观察瘤内注射碘油化疗药乳剂(CALE)治疗兔VX2瘤疗效。方法:12只荷瘤兔(24瘤灶)随机分3组,行瘤内注射碘油(碘油组)、化疗药物(化疗药组)和CALE(CALE组)2 ml,对照组2只4瘤灶。术后7 d处死:计算瘤体坏死率。取材行镜下观察。结果:肿瘤坏死率:碘油组(2.22±0.56)%;化疗药组(7.25±0.82)%;CALE组(27.02±3.46)%,3组间有显著差异(P<0.01),CALE组最高。病理:CALE组治疗效果最明显呈大片凝固坏死,瘤细胞碎裂;电镜见均质化无结构。结论:经皮瘤内注射CALE可引起肿瘤明显坏死,治疗疗效好。

Objective：To assess the therapeutic effect of percutaneous intratumoral injection with chemotherapic agents lipiodol emulsion （ CALE ） on implanted VX2 tumor in rabbits. Methods： According to the different agents injected into the tumors, 12 New Zealand rabbits implanted VX2 tumor tissue （ 24 models ） were divided into 3 groups （ lipiodol - group, drug -in group and CALE - group ） randomly. The pathologic changes of all lesions were observed the seventh day after the operation. Results： Compared with the lipiodol - group and drug - group, the highest tumor necrotic rate and greatest tumor pathological necrosis were found in the CALE -group（ P 〈0.01 ）. Conclusion ： Percutaneous intralesional injection of CALE is an effective ablation therapeutic method for the malignant solid tumors.