血清和诱导痰中白介素-6在高原地区慢性肺心病发病中的作用和临床意义

Effect of IL-6 in the patients with chronic cor pulmonale at high altitude

目的:探讨白介素-6(IL-6)在高原慢性肺心病发病机制中的作用和意义。方法:高原慢性肺心病急性加重期患者50例(A组)、缓解期患者47例(B组),健康对照组40例(C组),分别测血清和诱导痰中IL-6、肺功能和血气。结果:A、B组血清和诱导痰中IL-6、PaCO2水平显著高于C组(P均<0.01),FEV1%、FEV1/FVC、PaO2水平显著低于C组(P均<0.01);A、B组之间比较差异有显著性(P均<0.01);A、B组诱导痰中IL-6水平均显著高于血清(P均<0.01)。A、B组血清和诱导痰中IL-6与FEV1%、FEV1/FVC、PaO2呈显著负相关(P均<0.01),与PaCO2呈显著正相关(P均<0.01)。结论:IL-6参与了高原慢性肺心病的气道炎症反应。

Objective ：To investigate the effect of IL - 6 in the patients with high altitude chronic cor pulmonale （HACCP）. Methods： A total of 50 patients in acute stage of HACCP（ group A ） , 47 patients in remission stage （ group B） ,40 healthy volunteers as controls （ group C） were studied. The level of IL -6 in serum and induced sputum, lung function and arterial blood gas were measured. Results：The level of IL -6 in serum and induced sputum, PaCO2 in group A and group B were significantly higher than those in group C （ P 〈 0.01 ）, and FEV1%, FEV1/FVC and PaO2 were significantly lower than those in group C （P 〈0.01 ） ; there were significant differences between the group A and group B （P 〈0.01 ）. The level of IL-6 in induced sputum was significantly higher than that in serum in group A and group B （all P 〈0.01 ）. IL-6 level showed a negative correlation with FEV1%, FEV1/FVC, PaO： and a positive correlation with PaCO2 in group A and group B （P 〈 0.01 ）. Conclusion：IL -6 may participate in pathogenesis of airway inflammatory process of HACCP.