溶血葡萄球菌耐药性监测分析

Analysis of antimicrobial resistance of Staphylococcus haemolyticus

目的研究临床分离溶血葡萄球菌医院感染现状及对常用抗菌药物的耐药情况。方法采用琼脂对倍稀释法测定16种抗菌药物对临床分离溶血葡萄球菌株的最低抑菌浓度(MIC)值,对药敏结果用SPSS 13.0软件进行统计学分析。结果 2年间安徽省临床分离的溶血葡萄球菌中无万古霉素、替考拉宁耐药株;对青霉素、苯唑西林耐药率达90%以上,对头孢菌素类、大环内酯类、喹诺酮类抗菌药物的耐药率均在50%以上,甲氧西林耐药溶血葡萄球菌(MRSH)分别占59%、74.1%,显示出多重耐药现象。结论溶血葡萄球菌已成为临床葡萄球菌感染中较常见的致病菌,MRSH的多重耐药率高,需引起临床重视,应加强细菌耐药监控。

Objective To further investigate the clinical distribution and resistance of Staphylococcus haemolyticus to antimicrobial agents among clinical isolates.Methods Agar dilution method was performed to detect the minimal inhibition concentration（MIC） of 16 antimicrobial agents against Staphylococcus haemolyticus collected from clinical specimens.The antimicrobial resistance rates were analyzed by SPSS13.0 softrare.Results No Staphylococcus haemolyticus strain was resistant to vaneomycin and teicoplanin of this two years.The resistance rates to Penicillin G and Oxacillin were higher than 90%.And they were all higher than 50% to Cefalosporins,Macrolides,quinolones antibiotics.It also showed varying degrees of multiply resistance to Methicillin-resistant Staphylococcus haemolyticus（MRSH） which accounted for 59% and 74.1%.Conclusion It is noted that SH has become more common in Staphylococcus infections and MRSH showed multiply resistance to majority of the antibiotics.It must be monitored more frequently.